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目的了解广州市天河区妇科门诊成年女性人乳头瘤病毒(HPV)的感染流行特征,为制定HPV感染的预防策略提供科学依据。方法采用核酸分子快速导流杂交基因芯片技术对天河区南方医科大学第三附属医院及广州暨南大学附属第一医院妇科门诊的2 548例成年女性行HPVDNA检测。结果在2 548例成年女性样本中,所能检测的21种HPV亚型中,HPV阳性样本共745例,总感染率为29.24%,其中高危型感染共695例(含多重感染),占总阳性例数的93.29%,低危型感染共103例(含多重感染),占总阳性例数的13.83%。感染年龄组以31~35岁年龄组最高,21~35岁年龄段的3个组的阳性率均超过30%;检出的高危亚型中,前3种型别由高到低依次为HPV16型、HPV52型、HPV58型;低危亚型,前2种型别分别为HPV6型、HPV11型。结论该地区妇科门诊成年女性HPV总体感染率为29.24%,且以高危型为主,应加强对宫颈癌的早期预防和早期治疗。
Objective To understand the prevalence of human papillomavirus (HPV) infection in gynecological outpatient department of Tianhe District, Guangzhou, and to provide a scientific basis for the prevention strategy of HPV infection. Methods Rapid detection of HPVDNA was performed in 2 548 adult women in the Third Affiliated Hospital of Southern Medical University in Tianhe District and the First Affiliated Hospital of Jinan University in Guangzhou. Results Among 2 548 adult female samples, 745 HPV positive samples were detected in all HPV subtypes, with a total infection rate of 29.24%, of which 695 were high-risk infections (including multiple infections) 93.29% positive cases, 103 cases of low-risk infections (including multiple infections), accounting for 13.83% of the total positive cases. The infection age group was the highest in the 31-35 age group and the positive rate was more than 30% in the three groups of 21-35 age group. Among the high-risk subtypes detected, the top three types were HPV16 Type, HPV52 type, HPV58 type; low-risk subtype, the first two types were HPV6 type, HPV11 type. Conclusion The prevalence of HPV infection in adult women in gynecology outpatient department in this area was 29.24%. High-risk type was the mainstay. Early prevention and early treatment of cervical cancer should be strengthened.