目的　探讨系统性红斑狼疮 (SLE)合并中枢感染的诊断及鉴别诊断。方法　对 1994年以来诊断为SLE合并中枢感染的 14例病人进行回顾性分析。结果　 14例病人合并中枢感染前均长期使用激素。诊断隐球菌脑膜炎 4例 ,化脓性脑膜炎 3例 ,结核性脑膜炎 5例 ,脑脓肿 1例 ,诊断不明 1例。结论　脑脊液中发现病原微生物是确诊SLE合并中枢感染的可靠依据。无病原微生物证据的病人 ,中枢感染的诊断需综合判断。SLE中枢感染要与SLE脑病鉴别 Objective To investigate the diagnosis and differential diagnosis of systemic lupus erythematosus (SLE) complicated with central infection. Methods A retrospective analysis was performed on 14 patients diagnosed as SLE complicated with central infection since 1994. Results 14 patients with long-term use of hormones before central infection. Diagnosis of cryptococcal meningitis in 4 cases, 3 cases of purulent meningitis, tuberculous meningitis in 5 cases, 1 case of brain abscess, 1 case of unknown diagnosis. Conclusions Pathogenic microorganisms found in cerebrospinal fluid are a reliable basis for the diagnosis of central infection with SLE. Patients without evidence of pathogenic microorganisms, the diagnosis of central infection need to be judged synthetically. SLE central infection with SLE encephalopathy identification