目的探讨抗结核药致药物性肝炎的临床特点及诊治措施。方法回顾分析65例患者的临床资料。结果急性肝炎型和脂肪肝型:39例1月内肝功能完全正常;急性肝内胆汁淤积型:1月内肝功正常12例;混合型:1月内肝功正常1例。病程>2月的患者常伴有肝内胆汁淤积;死亡2例,死亡患者均合并病毒性肝炎;结果表明,伴有肝内胆汁淤积者病程长、恢复慢;有肝病基础的患者病情重、预后差;肝功恢复时间与肝损伤的严重程度呈正相关;重肝的发生与抗痨药使用时间无明显相关。结论对有药物性肝病史的患者,避免再度给予同类药物应定期监测肝功能,若仍需采用原药,则需慎重用药并严密观察。 Objective To investigate the clinical features and diagnosis and treatment of anti-tuberculosis drug-induced hepatitis. Methods The clinical data of 65 patients were retrospectively analyzed. Results Acute hepatitis and fatty liver type: 39 cases of normal liver function within 1 month; acute intrahepatic cholestasis type: 12 cases of normal liver function within 1 month; mixed type: normal liver function in 1 month. Course of disease> 2 months of patients often accompanied by intrahepatic cholestasis; 2 died, the death of patients were complicated with viral hepatitis; results showed that patients with intrahepatic cholestasis long duration, slow recovery; patients with liver disease based on serious illness, Poor prognosis; liver function recovery time and the severity of liver injury was positively correlated; the occurrence of severe hepatitis and anti-tuberculosis drug use time was not significantly correlated. Conclusion For patients with history of drug-induced liver disease, to avoid re-given similar drugs should be regularly monitored liver function, if still need to use the original drug, you need to be careful medication and close observation.