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1例2岁4个月男性川崎病患儿接受人免疫球蛋白15 g静脉滴注、1次/d，注射用果糖二磷酸钠2.2 g静脉滴注、1次/d，阿司匹林肠溶片200 mg口服、3次/d。2 d后停用人免疫球蛋白，3 d后将阿司匹林肠溶片减量为75 mg、1次/d。治疗前患儿肝功能正常。治疗第5天，实验室检查示丙氨酸转氨酶（ALT）897 U/L，天冬氨酸转氨酶（AST）905 U/L，乳酸脱氢酶（LDH）1 525 U/L。考虑可能为阿司匹林肠溶片所致药物性肝损伤。停用阿司匹林，更换为硫酸氢氯吡格雷，并给予谷胱甘肽、肝水解肽保肝治疗。14 d后，ALT 323 U/L，AST 66 U/L，LDH 297 U/L；20 d后，ALT 27 U/L，AST 45 U/L。“,”A 28-month-old boy with Kawasaki disease received IV infusions of human immunoglobulin 15 g and sodium fructose diphosphate for injection 2.2 g once daily, and oral aspirin enteric-coated tablets 200 mg thrice daily. Two days after the treatments, the human immunoglobulin was stopped. Three days after the treatments, the dose of aspirin enteric-coated tablets was reduced to 75 mg once daily. The boy′s liver function was normal before the treatments. On the 5th day of treatments, laboratory tests showed that alanine aminotransferase (ALT) was 897 U/L, aspartate aminotransferase (AST) was 905 U/L, and lactate dehydrogenase (LDH) was 1 525 U/L. Drug-induced liver injury caused by aspirin enteric-coated tablets was considered. Aspirin was stopped and replaced by clopidogrel hydrogen sulfate, and glutathione and heparolysate were given for liver protection. Laboratory tests showed ALT 323 U/L, AST 66 U/L, and LDH 297 U/L 14 days later and ALT 27 U/L and AST 45 U/L 20 days later.