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目的:探讨葛花醒酒汤联合纳洛酮治疗急性重度酒精中毒的临床疗效。方法:将133例急性重度酒精中毒患者随机分为对照组(68例)和治疗组(65例),两组患者均接受常规治疗,同时给予对照组患者纳洛酮治疗,治疗组在对照组治疗基础上加服葛花醒酒汤(葛花,葛根,枳椇子,五味子,茯苓,白术,砂仁组成)口服。比较两组的临床疗效及患者苏醒后临床症状。结果:治疗组患者清醒时间、症状缓解时间及出院时间显著早于对照组,(P<0.05)。观察组患者苏醒后头痛、头晕、恶心、呕吐、胸闷、反酸等临床症状发生率显著低于对照组(P<0.05)。结论:葛花醒酒汤联合纳洛酮治疗急性重度酒精中毒具有协同作用,疗效确切。
Objective: To investigate the clinical efficacy of Gehuoxuetang combined with naloxone in the treatment of acute severe alcoholism. Methods: A total of 133 patients with acute severe alcoholism were randomly divided into control group (n = 68) and treatment group (n = 65). Both groups received routine treatment and naloxone treatment was given to the control group. In the control group On the basis of treatment plus serving Ge Hua Xing Tang (Pueraria lobata, Pueraria lobata, Hovenia Dulcis, Schisandra, Poria, Atractylodes, Amomum composition) orally. The clinical efficacy of the two groups was compared with the clinical symptoms of the patients after waking up. Results: The awake time, symptom relief time and discharge time in the treatment group were significantly earlier than those in the control group (P <0.05). The incidence of clinical symptoms such as headache, dizziness, nausea, vomiting, chest tightness and acid reflux were significantly lower in the observation group than those in the control group (P <0.05). Conclusion: Pueraria Decoction combined with naloxone in the treatment of acute severe alcoholism has a synergistic effect.