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目的探讨高级别脑胶质瘤术后不同放化疗时序及程序对无进展生存期的影响。方法选择我院2011-05—2013-05收治的高级别脑胶质瘤患者80例,随机分为2组,分别给予放化疗+化疗以及早期化疗+同步放化疗+辅助化疗。观察记录2组临床疗效,并进行比较。结果经COX多因素分析,病理分级、KPS评分、术前抽搐、肿瘤切除范围对患者的预后存在影响(均P<0.05);治疗5个月,2组CBR比较差异无统计学意义(P>0.05);治疗8个月,2组CBR比较差异有统计学意义(P<0.05);2组中位OS比较差异无统计学意义(P>0.05);2组中位PFS比较差异有统计学意义(P<0.05)。结论高级别脑胶质瘤术后予以早期化疗+同步放化+辅助化疗可有效延长患者的无进展生存期。
Objective To investigate the effect of different chemoradiation timing and procedure on progression-free survival after high-grade glioma surgery. Methods Eighty patients with high-grade gliomas admitted to our hospital from 2011-05-2013-05 were randomly divided into two groups, which were given radiotherapy and chemotherapy combined with chemotherapy and early chemotherapy combined with chemoradiotherapy plus adjuvant chemotherapy respectively. Observed and recorded the clinical efficacy of two groups, and compared. Results The prognosis of patients was influenced by COX multivariate analysis, pathological grade, KPS score, preoperative tics and tumor resection (all P <0.05). There was no significant difference in CBR between the two groups after 5 months of treatment (P> 0.05). There was no significant difference in median OS between the two groups (P> 0.05). There was significant difference in median PFS between the two groups Significance (P <0.05). Conclusion High-grade glioma after surgery to be treated with early chemotherapy + concurrent radiotherapy + adjuvant chemotherapy can effectively prolong the progression-free survival of patients.