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目的评价唑来膦酸治疗恶性肿瘤引起骨转移疼痛的有效性和安全性。方法 22例恶性肿瘤骨转移性疼痛的患者每次给予唑来膦酸注射用4mg,加入0.9%氯化钠注射液100ml中,静脉滴注15min以上,每4周1次,至少连续2次以上。结果治疗骨转移灶止痛效果:完全缓解(1/22)4.5%,明显缓解(5/22)22.7%,中度缓解(10/22)45.5%,轻度缓解(6/22)27.3%,中位起效缓解时间第2天,中位缓解持续时间26d。主要不良反应为发热,消化道反应,流感样症状,低血磷及低血钙,但反应轻,不需特殊处理。结论唑来膦酸治疗恶性肿瘤骨转移有明显镇痛效果,药效维持时间长,不良反应轻,患者易接受。
Objective To evaluate the efficacy and safety of zoledronic acid in the treatment of malignant tumors with bone metastases. Methods Twenty-two patients with bone metastatic pain of malignant tumor were treated with 4 mg of zoledronic acid for injection and 100 ml of 0.9% sodium chloride injection intravenously for 15 minutes or more every 4 weeks for at least 2 times . Results The analgesic effect of treating bone metastases was as follows: 4.5% of complete remission (1/22), 22.7% of moderate remission (10/22), 45.5% of mild remission (6/22), 27.3% of moderate remission (6/22) Median onset of remission on the 2nd day, the median duration of remission 26d. The main adverse reactions were fever, digestive tract reaction, flu-like symptoms, hypophosphatemia and hypocalcemia, but the reaction was light, without special treatment. Conclusion Zoledronic acid treatment of malignant tumor bone metastasis significant analgesic effect of long-term efficacy, adverse reactions, patients are easy to accept.