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CD14是一种糖基磷脂酰肌醇锚定蛋白,作为细胞表面和内体中Toll样受体(TLR)的辅受体,在细菌、病毒、真菌等感染过程中具有关键作用。CD14主要通过髓样分化因子88(My D88)依赖型信号通路、β干扰素诱导的含TIR结构域接头蛋白(TRIF)依赖型信号通路、Ca2+/活化T细胞核因子(NFAT)信号通路参与机体固有免疫应答。CD14与多种疾病相关,在宿主抵御感染中具有双重作用。如在实验性脓毒症中,抑制CD14具有保护作用,但在肠道感染模型中,抑制CD14增加组织损伤。本文主要围绕CD14表达调控及其参与机体固有免疫应答抵御感染中的信号转导机制进行综述。
CD14 is a glycosylphosphatidylinositol-anchored protein that plays a key role in the infection of bacteria, viruses and fungi as co-receptors of Toll-like receptors (TLRs) on the cell surface and in endosomes. CD14 mainly participates in the intrinsic structure of the organism through the My D88-dependent signaling pathway, the beta interferon-induced TIR-containing domain adapter protein (TRIF) -dependent signaling pathway, and the Ca2 + / activated T cell nuclear factor (NFAT) signaling pathway Immune response. CD14 is associated with a variety of diseases and plays a dual role in host defense against infection. As in experimental sepsis, inhibition of CD14 has a protective effect, but in a model of intestinal infection, inhibition of CD14 increases tissue damage. This review focuses on the regulation of CD14 expression and the signaling transduction mechanisms involved in the innate immune response against infections.