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目的探讨病毒性心肌炎患者血清心肌酶谱及多项白介素水平的变化情况及其临床意义。方法我院诊治的30例病毒性心肌炎患者作为观察组,选取同期30例健康体检者作为对照组研究对象,通过酶联免疫吸附法,测定白介素IL-18、IL-6水平,通过全自动生化仪测定心肌酶谱(肌酸激酶CK、肌酸激酶同工酶CK-MB)水平。结果与对照组相比,观察组的IL-18、IL-6水平,以及CK和CK-MB水平均明显升高,P<0.05,差异有统计学意义。结论心肌酶谱和白介素指标的变化可以较为准确地反应心肌病变程度,有利于患者预后情况的判断,值得临床推广。
Objective To investigate the changes of serum myocardial enzymes and interleukin levels in patients with viral myocarditis and its clinical significance. Methods Thirty patients with viral myocarditis diagnosed and treated in our hospital were selected as observation group. Thirty healthy subjects were selected as the control group. The levels of IL-18 and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA) The myocardial enzyme profiles (creatine kinase CK, creatine kinase isoenzyme CK-MB) were measured. Results Compared with the control group, the levels of IL-18, IL-6 and the levels of CK and CK-MB in the observation group were significantly increased, P <0.05, the difference was statistically significant. Conclusion The changes of myocardial enzymes and interleukin indicators can reflect the degree of myocardial lesions more accurately, which is in favor of the prognosis of patients and is worthy of clinical promotion.