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目的:研究大鼠在航天推进剂四氧化二氮染毒后的图形视觉诱发电位改变。方法:正常雄性Winstar大鼠分3组,每组6~10只,其中一组用7.5mg、一组用15mg的四氧化二氮溶液进行ip染毒,一组为正常对照,每组均在晚上固定的时间进行图形视觉诱发电位检查。用SPSS10.0统计软件对数据进行分析。结果:正常大鼠与染毒大鼠之间及两组染毒大鼠之间的图形视觉诱发电位p100波的潜伏期的差异无统计学意义;正常大鼠与染毒大鼠之间及两组染毒大鼠之间的图形视觉诱发电位p100波的波幅值的差异亦无统计学意义。结论:四氧化二氮染毒对大鼠图形视觉诱发电位p100波具有一定程度的影响,表现为潜伏期稍延长,波幅值在剂量低时稍升高,剂量高时则降低,而且它们的变异多加大,其影响与染毒剂量有关,剂量大者,其变异更明显。但是其差异均无统计学意义。
OBJECTIVE: To study the change of graphic visual evoked potentials in rats after the aerosol propellants of nitrous oxide. Methods: Normal male Winstar rats were divided into 3 groups of 6 to 10, one group with 7.5mg, a group with 15mg of nitrous oxide solution for ip exposure, a group of normal control, each group were Graphic fixed-time visual evoked potential test. Using SPSS10.0 statistical software to analyze the data. Results: There was no significant difference in latency of p100 between the normal rats and the exposed rats and between the two groups There was no significant difference in the amplitudes of the p100 wave of visual evoked potentials between the exposed rats. CONCLUSION: Nitrous oxide exposure has some effect on the p100 wave of visual evoked potentials in rats. It shows a slightly prolonged incubation period, a slight increase of amplitude at low dose, and a decrease at high dose, and their variations More and more, its impact and dose-related, large doses, the more obvious variations. However, the differences were not statistically significant.