目的:观察中药直流电离子导入联合益肺养阴胶囊治疗小儿咳嗽变异性哮喘(CVA)的中医临床疗效。方法:CVA患儿共93例,对照组31例予辅舒酮吸入及支气管扩张剂治疗,治疗1组30例在以上对照组治疗基础上,首周加予中药直流电离子导入;其后则单纯以口服益肺养阴胶囊治疗。治疗2组32例在对照组治疗基础上,首周予加中药直流电离子导入治疗;其后在对照组缓解期治疗方案的基础上加服益肺养阴胶囊口服。总疗程3月。结果:治疗首周后,中药直流电离子导入组(治疗1组与治疗2组)在咳嗽单症状评分及症状总评分方面均优于对照组(P<0.05),而咽痒及痰量症状评分则无显著性差异。治疗结束后,治疗2组在咳嗽、咽痒及总症状评分方面均优于对照组(P<0.05)。对照组在咳嗽单症状及症状总评分上均显著优于治疗1组(P<0.01)。两治疗组比较,治疗2组在咳嗽、咽痒及总症状评分方面均优于治疗1组(P<0.01)。比较中医证候疗效时发现,对照组总有效率为80.6%,治疗1组为76.7%,治疗2组为93.6%,治疗2组要高于其余两组,但尚未构成统计学差异;治疗1组与对照组两者比较亦无显著性差异;控显率方面,对照组、治疗1组及治疗2组分别为61.3%、60.0%及84.4%,治疗2组与其余两组差异显著(P<0.05),治疗1组与对照组则无显著性差异。同时,治疗后的三组患者血清IgE及FeNO与治疗前比较差异显著(P<0.01);治疗2组治疗后FeNO优于治疗1组及对照组(P<0.05);对照组的IgE、FeNO较治疗1组下降更显著(P<0.01)。所有患者在接受治疗方案规定的治疗剂量和疗程中未出现严重不良反应。结论:在西医常规治疗基础上加用中药直流电离子导入能更迅速有效地缓解CVA患儿的症状。益肺养阴胶囊治疗小儿CVA的疗效确切,当与西医常规联用时具有更高的控显率。 Objective: To observe the clinical efficacy of traditional Chinese medicine (DC) iontophoresis combined with Yifang Yangyin Capsule in treating children with cough variant asthma (CVA). Methods: A total of 93 children with CVA were enrolled. In the control group, 31 patients were treated with inhalation of inhaled ketones and bronchodilators. Thirty patients in control group were treated with DC in the first week after treatment with the above control group. Yifei Yangyin capsule treatment. Treatment two groups of 32 patients in the control group based on the treatment, the first week plus Chinese medicine DC iontophoresis; followed by the control group remission based on the treatment program plus Yifei Yangyin capsule oral. The total course of treatment in March. Results: After the first week of treatment, DCI group (treatment 1 group and treatment 2 group) was better than the control group (P <0.05) in single cough symptom score and symptom score (P <0.05), while symptom score of throat and sputum No significant difference. After the treatment, the treatment group 2 was better than the control group in cough, itchy throat and total symptom score (P <0.05). The control group was significantly better than the treatment group 1 in the single symptom of cough and symptom score (P <0.01). The two treatment groups, the treatment group 2 cough, itching and the total symptom score were better than the treatment group 1 (P <0.01). Compared with the TCM syndromes, the total effective rate was 80.6% in the control group, 76.7% in the treatment group 1, 93.6% in the treatment group 2, and higher in the treatment group 2 than the other two groups, but the difference was not statistically significant. Treatment 1 There was no significant difference between the two groups in the control group, the control group, the treatment group 1 and the treatment group 2 were 61.3%, 60.0% and 84.4% respectively, the difference between the treatment group 2 and the other two groups was significant (P <0.05). There was no significant difference between treatment group 1 and control group. At the same time, serum IgE and FeNO in the three groups after treatment were significantly different from those before treatment (P <0.01); FeNO in treatment group 2 was better than that in treatment 1 group and control group (P <0.05); IgE and FeNO Compared with the treatment group 1 decreased more significantly (P <0.01). All patients did not experience serious adverse reactions at the dose and course of treatment prescribed for the treatment regimen. Conclusion: It is more effective and quicker to relieve the symptoms of children with CVA based on the routine treatment of traditional Chinese medicine plus DC ion implantation. Yifang Yangyin capsule treatment of infantile CVA exact effect, when combined with conventional Western medicine has a higher control rate.