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目的探讨脑脊液和血液神经元特异性烯醇化酶(NSE)水平在判断惊厥性脑损伤中作用。方法以60例患儿作为研究对象,分为非神经系统疾病组、周围神经疾病组、短程惊厥组和长程/持续惊厥组,比较各组脑脊液和血清NSE水平差异;同时观察惊厥患儿脑电图和头颅影像学改变。结果惊厥发作后患儿血清和脑脊液NSE水平升高,且长程/持续惊厥组NSE水平升高更为明显;NSE在血清及脑脊液水平变化具有一致性;长程/持续惊厥组脑电图异常阳性率明显高于短程惊厥组,而两组头颅影像学方面改变无显著差异。结论NSE检测有助于及时判断惊厥性脑损伤,与脑电图反映脑功能受损意义一致,且较头颅影像学改变更敏感。惊厥后及时动态观察血清或脑脊液NSE水平变化,并结合脑电图检查对判断脑损伤程度及预后有重要价值。
Objective To investigate the role of cerebrospinal fluid (CSF) and blood neuron specific enolase (NSE) levels in judging convulsant brain injury. Methods Sixty children were included in the study. The patients were divided into non-neurological disease group, peripheral nerve disease group, short-term convulsion group and long-term / persistent convulsion group. The differences of CSF NSE levels and serum NSE levels were compared between the two groups. Figure and head imaging changes. Results The levels of NSE in serum and cerebrospinal fluid of children with seizures increased after the seizures, and the levels of NSE in the long-term / persistent seizure group were more obvious. The changes of NSE in serum and cerebrospinal fluid were consistent. The abnormal positive rate of EEG in long-term / persistent seizure group Significantly higher than the short-range convulsions group, while there was no significant difference between the two groups in the head imaging. Conclusions NSE can be helpful in judging convulsive brain injury in time, which is consistent with the implication of impaired brain function by EEG and more sensitive than the change of head imaging. After the seizures timely and dynamic observation of serum or cerebrospinal fluid NSE levels, combined with EEG examination to determine the extent of brain injury and prognosis of great value.