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本文调查了９８名铬（Ｃｒ）作业工人和５８名镉（Ｃｄ）作业工人尿中γ－ＧＴ同功酶的变化。在Ｃｒ作业工人中，当受检者尿蛋白和尿民β＿２－ＭＧ均在正常范围内时，尿γ－ＧＴ、γ－ＧＴⅠ和γ－ＧＴⅡ活性已开始显著高于对照组，随肾损害程度加重，尿γ－ＧＴ、γ－ＧＴⅠ和γ－ＧＴⅡ活性呈明显的升高趋势，但γ－ＧＴⅠ／γ－ＧＴⅡ与对照组比较均未见显著变化；这似可提示尿γ－ＧＴ总酶和同功酶均可作为检测铬性肾损害较灵敏的指标，这对早期诊断和防治佑性肾损害有一定的理论意义和实用参考价值。在Ｃｄ作业工人中，所有Ｃｄ作业工人尿中γ－ＧＴ、γ－ＧＴⅠ、γ－ＧＴⅡ均超出正常值上限；随肾损伤程度的加重，尿γ－ＧＴ、γ－ＧＴⅠ明显升高，而且γ－ＧＴⅠ／γ－ＧＴⅡ呈下降趋势，在重度肾损伤的Ｃｄ作业工人中，尿γ－ＧＴⅠ／γ－ＧＴⅡ由正常的６．０２下降到３．７３；结果提示，尿γ－ＧＴ可能作为Ｃｄ接触者健康监测的一个敏感指标；尿γ－ＧＴⅠ／γ－ＧＴⅡ的变化似与Ｃｄ作业工人肾损伤程度有密切关系，其机理值得进一步研究。
This article investigated urinary gamma-GT isoenzyme changes in 98 chromium (Cr) workers and 58 cadmium (Cd) workers. Urinary γ-GT, γ-GTⅠ and γ-GTⅡ activities of urinary γ-GT, γ-GTⅠ and γ-GTⅡ in Cr workers started to be significantly higher than those in controls when urinary protein and urinary β_2-MG were within the normal range. The urinary γ-GT, γ-GTⅠ and γ-GTⅡ activities increased obviously, but there was no significant difference between γ-GTⅠ / γ-GTⅡ and the control group And isoenzyme can be used as indicators of detection of chromium nephrosclerosis more sensitive, which early diagnosis and prevention and treatment of kidney damage have some theoretical significance and practical reference value. Urine γ-GT, γ-GTⅠ and γ-GTⅡ in Cd-exposed workers all exceeded the upper limit of normal. Urine γ-GT and γ-GTⅠ increased significantly with the severity of renal injury, and γ -GTⅠ / γ-GTⅡ showed a decreasing trend. Urine γ-GTⅠ / γ-GTⅡ decreased from normal 6.02 to 3.73 in Cd-exposed workers with severe renal injury. The results suggest that urinary γ-GT may be used as Cd Contact health monitoring of a sensitive indicator; urinary γ-GT Ⅰ / γ-GT Ⅱ changes and cadmium workers seem to have a close relationship between the degree of renal injury, the mechanism deserves further study.