论文部分内容阅读
目的:观察参芪心复康对心气虚证动物模型的影响,筛选治疗心气虚证的有效方药。方法:16只NIH小白鼠采用连续控食,强迫负重游泳,大剂量灌服心得安和注射垂体后叶素等综合方法制造心气虚证动物模型。造模动物随机分为实验组和对照组。实验组动物每日加服参芪心复康煎液0.5ml(含参芪心复康生药0.5g/ml);对照组动物每日加服生理盐水0.5ml。结果:心气虚证动物灌服参芪心复康后,负重游泳时间延长,心率加快,心功能改善,SOD活性上升,MDA、LDH、CKW含量降低,与对照组比较差别有显著性(P<0.05)或高度显著性(P<0.01)。结论:参芪心复康对心气虚证有较好的防治作用。
OBJECTIVE: To observe the effect of Shenqixinfukang on the animal model of Qi-deficiency syndrome and to screen the effective prescriptions for the treatment of heart-qi deficiency syndrome. Methods: Sixteen NIH mice were fed with continuous control of food, forced weight-bearing swimming, large doses of propranolol injection and pituitrin injection to make the animal model of heart-qi deficiency. Model animals were randomly divided into experimental and control groups. Animals in the experimental group were treated with Shenqixinfujian decoction (0.5ml/ml) daily for 5 days. Rats in the control group were given daily physiological saline 0.5ml. RESULTS: After Shenqi Decoction was administrated by heart-qi deficiency rats, weight-bearing swimming time was prolonged, heart rate was increased, heart function was improved, SOD activity was increased, and MDA, LDH, and CKW levels were decreased. There was significant difference compared with the control group (P< 0.05) or highly significant (P<0.01). Conclusion: Shenqixinfukang has a good preventive and therapeutic effect on heart-qi deficiency syndrome.