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合成维甲酸的毒性一般与维生素A过量相似,主要波及皮肤、粘膜,也可见甘油三酯升高、肝功异常、畸形。此外,亦可见到脊椎强直及关节疼痛。作者对50名口服合成维甲酸药物达2年之久的患者进行X线检查,并与未接受合成维甲酸治疗的72名患者依年龄、性别匹配进行比较,以了解椎骨异常的发生情况。在接受合成维甲酸治疗的患者中,采用芳香维申酸者37名,采用13—顺维甲酸者13名,其中有9名患者开始采用13—顺维甲酸,而后又改为
The toxicity of synthetic retinoic acid is generally similar to excessive vitamin A, mainly affecting the skin and mucous membranes, but also shows elevated triglycerides, abnormal liver function, deformity. In addition, spinal rigidity and joint pain can also be seen. The authors performed X-ray examinations on 50 patients who had been taking synthetic retinoic acid for 2 years and compared them to age and sex with 72 patients who did not receive synthetic retinoic acid for age-matched vertebrae. Among patients receiving synthetic tretinoin therapy, 37 were treated with aromatic vinic acid, 13 were treated with 13-cis-retinoic acid, 9 of whom started 13-cis-retinoic acid and then changed to