论文部分内容阅读
目的探讨羟基磷灰石与聚乙烯复合材料(hydroxyapatite/high-density polyethylene composite,HA/PE)的组织相容性和可塑性。设计实验性研究。研究对象45只新西兰白兔。方法实验动物随机分为HA/PE复合材料、多孔HA材料和多孔PE材料植入组,每组各15只。三组动物分别于眶下缘植入HA/PE复合材料、多孔HA及多孔PE材料三种不同植入物,于术后1、4、8、12、24周行大体、光学显微镜、扫描电镜检查。主要指标植入物愈合及植入物内出现骨组织情况。结果植入物无脱出、移位,与周围组织愈合紧密。HA/PE组术后1周即有成纤维细胞及新生血管长入,术后12周及24周可见成骨细胞、骨细胞等骨组织。HA组术后8周可见成骨细胞,24周孔隙内充满骨细胞。PF组可见成纤维细胞及新生血管长入,未见骨组织。结论HA/PE既具有HA良好的生物相容性及骨传导性,又具有聚乙烯材料良好的可塑性,有望成为较理想的骨替代材料。
Objective To investigate the histocompatibility and plasticity of hydroxyapatite / high-density polyethylene composite (HA / PE). Design experimental research. Study object 45 New Zealand white rabbits. Methods Experimental animals were randomly divided into HA / PE composite material, porous HA material and porous PE material implantation group, 15 rats in each group. The three groups of animals were implanted with three different implants of HA / PE composite, porous HA and porous PE on the inferior orbital rim, respectively. At 1, 4, 8, 12 and 24 weeks after operation, an examination. The main indicators of implant healing and bone tissue within the implant situation. Results implants no prolapse, displacement, and the surrounding tissue healing. One week after HA / PE group, there were fibroblasts and neovascularization. Osteoblasts, osteocytes and other bone tissues were observed at 12 weeks and 24 weeks after operation. Osteoblasts were observed in HA group at 8 weeks postoperatively, and bone cells were filled in 24 weeks. PF group showed fibroblasts and neovascular growth, no bone tissue. Conclusion HA / PE not only has good biocompatibility and osteoconductivity of HA, but also has good plasticity of polyethylene. It is expected to be an ideal bone substitute material.