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目的探讨转录调节因子Ets-1在口腔鳞癌组织中的表达及其意义。方法应用PV-9000两步免疫组织化学染色法检测65例口腔鳞癌组织,13例正常口腔黏膜组织中Ets-1的表达。结果Ets-1在口腔鳞癌中的阳性表达率为92.3%,明显高于对照组(P<0.01);Ets-1的表达与口腔鳞癌颈淋巴结转移、TNM分期及分化程度相关(P<0.05),未发现Ets-1在口腔鳞癌组织中的阳性表达率与性别、年龄、肿瘤大小有关(P>0.05)。结论Ets-1在口腔鳞癌组织高表达,其阳性表达与病理学分级、淋巴结转移及TNM分期有关。
Objective To investigate the expression of transcriptional regulator Ets-1 in oral squamous cell carcinoma and its significance. Methods PV-9000 two-step immunohistochemical staining was used to detect the expression of Ets-1 in 65 cases of oral squamous cell carcinoma and 13 cases of normal oral mucosa. Results The positive expression rate of Ets-1 in oral squamous cell carcinoma was 92.3%, which was significantly higher than that in the control group (P <0.01). The expression of Ets-1 was correlated with cervical lymph node metastasis, TNM stage and differentiation (P < 0.05). The positive expression rate of Ets-1 in oral squamous cell carcinoma was not related to sex, age and tumor size (P> 0.05). Conclusion Ets-1 is overexpressed in oral squamous cell carcinoma. The positive expression of Ets-1 is correlated with pathological grade, lymph node metastasis and TNM staging.