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目的 探讨直肠癌根治性切除术后联合门静脉化疗对预防术后局部复发和肝转移的治疗效果。方法 对 1995年 1月至 1999年 10月本院收治的 6 0例直肠癌病人术前随机分为两组 ,即术后联合门静脉化疗治疗组 (PVC组 ) 30例 ,术后单纯外周静脉全身化疗组 (对照组 ) 30例 ,对其疗效进行临床观察分析。结果 治疗组 (PVC组 ) 3年生存率、局部复发率、肝转移率分别是 86 6 %、10 %、6 6 %。直肠癌根治术后联合门静脉化疗组 1～ 3年复发率比对照组明显低 ,生存率比对照组明显高 ,差异有非常显著意义 (P <0 0 1)。结论 直肠癌根治术后联合门静脉化疗可以明显降低局部复发率和肝转移率 ,提高 5年生存率和生存质量。
Objective To investigate the therapeutic effect of combined portal vein chemotherapy after radical resection of rectal cancer on prevention of local recurrence and liver metastasis. Methods Totally 60 patients with rectal cancer treated in our hospital from January 1995 to October 1999 were randomly divided into two groups: 30 patients in the postoperative combined with portal vein chemotherapy group (PVC group), 30 patients in the simple peripheral vein group Chemotherapy group (control group) 30 cases, its clinical efficacy analysis. Results The 3-year survival rate, local recurrence rate and liver metastasis rate of the treatment group (PVC group) were 86 6%, 10% and 6 6% respectively. The recurrence rate after 1 ~ 3 years in patients with rectal cancer combined with portal vein chemotherapy was significantly lower than that in control group, and the survival rate was significantly higher than that in control group (P <0.01). Conclusions Combined with portal vein chemotherapy after radical resection of rectal cancer can significantly reduce the local recurrence rate and liver metastasis rate and improve the 5-year survival rate and quality of life.