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目的:观察性别对小鼠H22腹水型肝癌生长情况的影响,研究不同性别动物对肝癌耐受性的差异。方法:取30只8周龄昆明鼠,雌雄各半,随机分为四组,实验组每组10只,对照组每组5只,腹腔接种小鼠H22肝癌细胞,建立小鼠H22腹水型肝癌模型。每天测量小鼠体重并记录生存时间,直至实验组小鼠全部死亡,比较性别因素对小鼠H22腹水型肝癌的生存期是否存在差异。结果:小鼠接种瘤细胞后,逐渐产生腹水,体重增加。雌性小鼠的体重增加比雄性小鼠显著,P=0.049。雄性小鼠生存后期体重出现下降,呈明显恶液质状态。雌性小鼠的体重、腹水增加虽然较雄性动物明显,但生存期却并不少于雄性鼠,反而比雄性小鼠略长,P=0.1567。结论:性别对小鼠H22腹水型肝癌的生长有一定的差异,雌性小鼠的耐受性优于雄性小鼠。
Objective: To observe the effects of sex on the growth of mouse H22 ascites hepatocellular carcinoma (HCC) and to study the differences of tolerance of hepatocarcinoma between different sexes. Methods: Thirty male Kunming mice of 8 weeks old were randomly divided into four groups. The experimental group was given 10 mice in each group. Five mice in each group were inoculated intraperitoneally with H22 hepatoma cells. H22 ascites hepatocellular carcinoma model. The body weight of the mice was measured daily and the survival time was recorded until all the mice in the experimental group died. The gender differences in the survival of the mouse H22 ascites hepatocellular carcinoma were compared. Results: After inoculation of tumor cells, mice gradually developed ascites and gained weight. Weight gain in female mice was significantly greater than in male mice, P = 0.049. Late male mice showed a decrease in body weight at the later stage of their life, showing a marked state of cachexia. Although the weight and ascites of female mice increased significantly compared with male animals, their survival time was not less than that of male mice, but slightly longer than that of male mice (P = 0.1567). Conclusion: There is a certain difference in gender between the growth of mouse H22 ascites hepatoma and the tolerance of female mice is better than that of male mice.