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目的:观察长期口服埃他卡林对高原脱习服的影响。方法:该临床研究采用随机双盲安慰剂平行对照试验方法,随机分为埃他卡林试验组和安慰剂对照组,两组受试者分别为39例和17例。其中,受试者分别口服埃他卡林片(5 mg/片,1次/日)或安慰剂(1片/日),连续服用药物7个月,下山到3700 m停留2 d并停止服药,再返回到海拔1400 m的平原地区,自返回平原的第2、4、6天,进行高原脱习服症状调查,随访受试者的高原脱习服症状并进行症状评分。结果:长期驻扎在5200～5380 m高海拔地区的受试者,返回平原后第2、4、6天,分别有82.4%、52.9%、23.5%的人员产生显著的高原脱习服症状,长期口服埃他卡林,高原脱习服发生率分别为43.6%、30.8%、38.5%;安慰剂对照组返回平原后脱习服反应程度的评分,在第2、4、6天分别为(6.0±1.9)、(4.6±1.0)、(3.8±1.5)分,埃他卡林治疗组分别为(4.4±2.4)、(3.3±1.8)、(4.0±1.5)分,两组比较,在返回低海拔第2、4天,高原脱习服反应的发病率及发病程度均显著减少,第6天的数据两组之间差别无统计学意义。结论:高原地区长期口服埃他卡林可显著减轻高原脱习服的发病程度,降低高原脱习服的发生率,预防高原脱习服。
OBJECTIVE: To observe the effect of long-term oral iptakalim on altitude uniforms. METHODS: This clinical trial was randomized, double-blind, placebo-controlled, randomized trial to the experimental and placebo groups, 39 and 17 subjects, respectively. Subjects were given either etanercept (5 mg / tablet, once daily) or placebo (1 tablet / day) orally for 7 months, down to 3700 m for 2 days and stopped , And then returned to the plain area of 1400 m above sea level. After returning to the plain on the 2nd, 4th, and 6th days, the symptoms of altitude sickness were investigated and the symptom scores of the subjects were observed. Results: On the 2nd, 4th, and 6th days after returning to the plain, 82.4%, 52.9% and 23.5% of the respondents who had been stationed in the high altitude area of 5200 ~ 5380 m for a long time had significant symptoms of altitude sickness, The incidence rates of oral ethakalim and highland uniforms were 43.6%, 30.8% and 38.5%, respectively. The scores of the response to placebo after returning to the plain in the placebo group were (6.0 ± (4.4 ± 2.4), (3.3 ± 1.8) and (4.0 ± 1.5) points respectively in the two groups, and the difference was statistically significant On the 2nd and 4th days of low altitude, the incidence and severity of off-duty reactions in the plateau decreased significantly. There was no significant difference between the two groups on the 6th day. CONCLUSION: Long-term oral iptakalim in the plateau can significantly reduce the incidence of altitude sickness, reduce the incidence of altitude sickness, and prevent altitude sickness.