[目的]研究手机使用与听神经瘤发病风险的关系,探讨手机使用的安全性。[方法]在线检索文献资料,分析手机使用与听神经瘤发病风险关系的病例对照研究,采用随机效应模型计算合并OR值,Meta回归筛选异质性影响因素,进行亚组分析。[结果]共纳入8篇文献,包括1527例听神经瘤患者和7636例对照。各研究存在异质性,随机效应模型结果表明,手机使用、长期使用与听神经瘤发病风险均无统计学关联,合并OR值分别为0.93(95%CI:0.75～1.16)和1.35(95%CI:0.81～2.25)。经Meta回归分析,以地区为异质性影响因素,做亚组分析。两亚组使用手机对听神经瘤的风险均未发现有显著影响,合并OR值分别为0.88(95%CI:0.77～1.00)和1.09(95%CI:0.80～1.51)。长期使用手机使听神经瘤发病风险增加,合并OR值分别为1.39(95%CI:1.12～1.73)和1.94(95%CI:1.30～2.89)。[结论]手机使用与听神经瘤的关联尚不能定论,但可能存在剂量—反应关系,需要进一步的研究。 [Objective] To study the relationship between the use of mobile phones and the incidence of acoustic neuroma, to explore the safety of mobile phones. [Methods] The literature data was searched online to analyze the case-control study on the relationship between the use of mobile phone and the incidence of acoustic neuroma. The random OR model was used to calculate the combined OR. Meta-regression was used to screen the heterogeneity factors for subgroup analysis. [Results] A total of 8 articles were included, including 1527 patients with acoustic neuroma and 7636 controls. The heterogeneity of each study, random effects model results show that the use of mobile phones, long-term use and the incidence of acoustic neuroma no statistically significant association, combined OR values ​​were 0.93 (95% CI: 0.75 to 1.16) and 1.35 (95% CI : 0.81 ~ 2.25). Meta-regression analysis, the region as a heterogeneous factors, do subgroup analysis. There was no significant difference in the risk of acoustic neuroma between the two subgroups using mobile phones. The pooled OR values ​​were 0.88 (95% CI: 0.77-1.00) and 1.09 (95% CI: 0.80-1.51), respectively. Long-term use of mobile phones increased the risk of acoustic neuroma, with a combined OR of 1.39 (95% CI: 1.12-1.73) and 1.94 (95% CI: 1.30-2.89), respectively. [Conclusion] The correlation between cellphone use and acoustic neuroma is still inconclusive, but dose-response relationship may exist and further research is needed.