一系列的研究表明,肺纤维化患者中肺癌的发病率较普通人群中肺癌发病率增高,在系统性硬化症、结节病、职业病等影响到肺间质的疾病中亦有此趋势[1 ] 。近期肺纤维化流行病学及分子、细胞生物学的一些研究,如炎症细胞间的相互作用导致肺实质的组织和结构破坏,为揭释其机制提供了 A series of studies have shown that the incidence of lung cancer in patients with pulmonary fibrosis is higher than the incidence of lung cancer in the general population and is also present in diseases affecting systemic lung disease such as systemic sclerosis, sarcoidosis, occupational diseases [1 ]. Recent epidemiology of pulmonary fibrosis and molecular, cell biology, some studies, such as the interaction between inflammatory cells lead to pulmonary parenchymal tissue and structural damage, to provide a mechanism for its interpretation