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目的 了解和比较重度缺碘地区口服碘油孕妇的子代与重度缺碘地区仅食用碘盐孕妇的子代和轻度缺碘地区未补碘孕妇的子代亚临床损伤状况。方法 采取CRT -C2 、JPB、测听仪、拍X线片、标准度衡器具检测同期出生的 3组 7～ 13岁儿童的智商、精神运动功能、听力、骨龄和身高、体重。结果 碘油预防组、碘盐预防组、未补碘组儿童的智商均值分别为98 2± 15 3 ,93 5± 15 7,94 2± 16 2 ,IQ5 0～ 69者分别占2 3 % ,7 1% ,7 5 % ;3组儿童JPB异常率为 1 0 % ,4 5 % ,4 4 % ,听力减退率为 1 9% ,5 4 % ,5 6% ,骨龄落后率为4 4 % ,7 4 % ,7 8% ,身高落后率为 4 2 % ,7 1% ,7 3 % ,体重落后率为 2 4 % ,4 3 % ,4 4 %。统计碘油预防组儿童智商均值显著高于碘盐预防组和未补碘组儿童 (P <0 0 0 1) ,碘油预防组儿童的轻度智力落后率、JPB异常率、听力减退率、骨龄和身高落后率则显著低于另两组儿童 (P <0 0 5 ) ,而碘盐预防组与末补碘组儿童各项亚临床损伤率差异无显著性意义 (P >0 1)。结论 孕妇服用碘油预防子代亚临床损伤的效果为佳 ,在尚未普及合格碘盐的重度缺碘地区对孕妇投服碘油是必要和可行的。
Objective To understand and compare the sub-clinical offspring of offspring of iodized oil pregnant women with severe iodine deficient areas and offspring of iodine-deficient pregnant women with severe iodine deficient areas and non-iodized pregnant women with mild iodine deficiency areas. Methods The IQ, motor function, hearing, bone age, height and weight of 3 children aged 7 ~ 13 born at the same period were detected by CRT-C2, JPB, audiometer, X-ray film and standard balance instrument. Results The mean IQ of children in iodized oil prevention group, iodized salt prevention group and non-iodized group were respectively 98 2 ± 15 3, 93 5 ± 15 7 and 94 2 ± 16 2, IQ 5 0-69 accounted for 23% The abnormal rate of JPB was 10%, 45%, 44%, the hearing loss rate was 19%, 54%, 56%, and the rate of bone age was 44% , 74%, 78% respectively. The height backward rate was 42%, 71%, 73%, and the body weight backwardness was 24%, 43%, 44% respectively. The average IQ of children with iodized oil prevention group was significantly higher than that of iodized salt prevention group and children without iodine supplementation (P0.01). The children with mild iodine deficiency prevention rate, JPB abnormal rate, hearing loss rate, The skeletal age and height backward rate were significantly lower than those in the other two groups (P <0.05). However, there was no significant difference in subclinical injury between iodine salt prevention group and iodine deficiency group (P> 0 1). Conclusions Pregnant women take iodized oil to prevent sub-clinical subclinical injury is better. It is necessary and feasible to administer iodized oil to pregnant women in areas with severe iodine deficiency, which have not been widely used.