论文部分内容阅读
目的观察细胞视黄酸结合蛋白Ⅱ(cellular retinoic acid-binding proteinⅡ,CRABPⅡ)和表皮型脂肪酸结合蛋白(epidermal fatty acid-binding protein,E-FABP)在乳腺浸润性导管癌(invasive ductal carcinoma,IDC)中的表达,探讨其与乳腺IDC临床病理特征的关系。方法采用免疫组化SP法检测43例正常乳腺组织、152例乳腺IDC原发组织以及93例淋巴结转移癌组织中CRABPⅡ和E-FABP的表达。结果 CRABPⅡ在正常乳腺组织中的阳性率高于乳腺IDC(P<0.05);E-FABP在乳腺IDC中的阳性率高于正常乳腺组织(P<0.05),其在乳腺IDC中的表达与肿瘤的转移有关(P<0.05),单因素和多因素生存分析均提示E-FABP阳性组的患者预后差(P<0.05)。结论 CRABPⅡ表达的减弱或缺失、E-FABP表达的增强可能与乳腺IDC的发生和演进相关;E-FABP阳性表达提示预后不良,对IDC患者预后的评估有一定价值。
OBJECTIVE: To observe the effect of cellular retinoic acid-binding protein Ⅱ (CRABPⅡ) and epidermal fatty acid-binding protein (E-FABP) on invasive ductal carcinoma (IDC) In order to explore its relationship with clinicopathological features of breast IDC. Methods Immunohistochemical SP method was used to detect the expression of CRABPⅡ and E-FABP in 43 cases of normal breast tissues, 152 cases of primary breast IDC tissues and 93 cases of metastatic lymph node tissues. Results The positive rate of CRABPⅡ in normal breast tissue was higher than that in breast IDC (P <0.05). The positive rate of E-FABP in breast IDC was higher than that in normal breast tissue (P <0.05) (P <0.05). Both univariate and multivariate survival analysis showed that the prognosis of E-FABP-positive patients was poor (P <0.05). Conclusions The decreased or absent expression of CRABPⅡ may enhance the expression of E-FABP in breast cancer. The positive expression of E-FABP may be related to the occurrence and progression of IDC. The positive expression of E-FABP suggests a poor prognosis, which may be of value in the prognosis evaluation.