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小柴胡汤合桂枝加芍药汤(TJ—960)是以小柴胡汤为基础方的新的汉方药,临床有显著的抗癫痫作用。但因其具有一定的致畸性,故对患癫痫的孕妇用药需同时考虑治疗效果和对胎儿的影响问题。这次,我们探讨TJ—960有无致畸性以及TJ—960和丙戊酸为代表的抗癫痫药同时应用对大白鼠胎仔的影响。研究表明,TJ—960用至3000mg/kg,未发现其有致畸作用,因而认为其无致畸性,
Xiaochaihu Decoction and Guizhi Jiayu Decoction (TJ-960) is a new Kampo medicine based on Xiaochaihu Decoction. It has clinically significant antiepileptic effect. However, due to its teratogenicity, it is necessary to consider the effects of treatment and effects on the fetus in pregnant women suffering from epilepsy. This time, we investigated the effects of TJ-960 with or without teratogenicity and the simultaneous application of anti-epileptic drugs represented by TJ-960 and valproic acid on fetuses in rats. Studies have shown that TJ-960 used to 3000mg/kg, did not find its teratogenic effect, and therefore that it is not teratogenic,