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右美托咪啶是高度特异选择性α2肾上腺素受体激动剂,它的分布半衰期为6 min,消除半衰期为2 h,较短的分布半衰期让它成为一种理想的静脉注射药。右美托咪啶具有镇静催眠、镇痛、抑制交感神经的作用,可使麻醉药用量明显减少,抑制气管插管、拔管时的应激反应,通常作为临床麻醉的辅助药和ICU镇静药。它是一种新型的、很有前途的麻醉辅助药。
Dexmedetomidine is a highly specific and selective α2-adrenoceptor agonist with a half-life of 6 min and an elimination half-life of 2 h, making it an ideal intravenous drug with a short half-life. Dexmedetomidine has the functions of sedation, hypnosis, analgesia and sympathetic inhibition, significantly reduces the amount of anesthetic used, inhibits endotracheal intubation and extubation stress response, and is usually used as auxiliary for clinical anesthesia and sedation of ICU medicine. It is a new and promising anesthetic adjuvant.