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目的探讨G蛋白抑制肽GCIP-27对多柔比星(Dox)诱导的大鼠慢性心力衰竭的作用。方法 48只SD大鼠随机分为对照组、模型组、氯沙坦组、GCIP-27组,分别给予生理盐水、Dox、Dox+氯沙坦、Dox+GCIP-27(10、30、90μg·kg~(-1),ip,bid)。给予Dox复制模型后,再继续喂养大鼠,于d71,经胸高频彩超诊断仪测定大鼠心功能;称量大鼠体重、心脏质量、左心室质量,计算心脏质量指数和左心室质量指数;HE染色后观察大鼠心肌组织病理形态学改变。结果 Dox可明显诱导大鼠发生慢性心力衰竭;氯沙坦6mg·kg~(-1)、GCIP-27(30、90μg·kg~(-1),bid)能明显抑制大鼠左心室重构,提高心脏的射血分数和短轴缩短率,降低心脏质量指数和左心室质量指数,减少心肌组织的损伤。结论 GCIP-27能抑制慢性心力衰竭大鼠的左心室重构,改善心脏功能。
Objective To investigate the effect of G-protein inhibitor GCIP-27 on doxorubicin-induced chronic heart failure in rats. Methods Forty-eight SD rats were randomly divided into control group, model group, losartan group and GCIP-27 group. The rats were given normal saline, Dox, Dox + losartan, Dox + GCIP- ~ (-1), ip, bid). After Dox model was given, the rats were further fed with rats. The heart function of rats was measured by d 71, and the body weight, heart mass, left ventricular mass, heart mass index and left ventricular mass index The pathological changes of myocardial tissue were observed by HE staining. Results Dox could obviously induce chronic heart failure in rats. Losartan 6 mg · kg -1 and GCIP-27 (30, 90 μg · kg -1, bid) significantly inhibited left ventricular remodeling , Improve cardiac ejection fraction and short axis shortening, reduce the heart mass index and left ventricular mass index, reduce myocardial injury. Conclusion GCIP-27 can inhibit left ventricular remodeling and improve cardiac function in rats with chronic heart failure.