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目的探讨血清甲胎蛋白(AFP)、糖类抗原125(CA125)及糖类抗原199(CA199)联合检测在宫颈恶性肿瘤诊断中的价值。方法选择宫颈恶性肿瘤患者321例作为恶性肿瘤组,宫颈良性病变患者225例作为良性病变组,健康体检者206例作为对照组。应用放射免疫法测定三组患者血清AFP、CA125及CA199阳性例数及表达水平,并计算出单一检测及联合检测时的敏感度、特异度、准确度。结果恶性肿瘤组患者血清AFP、CA125及CA199阳性比例及水平均高于良性病变组及正常组(P<0.05)。AFP+CEA+CA199三项联合时敏感度、特异度、准确度分别提高至67.25%、84.43%、78.92%,均高于各指标二者联合检测及单一检测时的结果 (P<0.05)。结论联合检测血清AFP、CA125及CA199能够提高宫颈恶性肿瘤的诊断效能。
Objective To investigate the value of combined detection of serum alpha-fetoprotein (AFP), carbohydrate antigen 125 (CA125) and carbohydrate antigen 199 (CA199) in the diagnosis of cervical cancer. Methods 321 patients with cervical cancer as malignant tumor group, 225 patients with benign cervical lesions as a benign lesion group, 206 healthy subjects as a control group. Radioimmunoassay was used to measure the positive cases and expression levels of serum AFP, CA125 and CA199 in three groups of patients, and the sensitivity, specificity and accuracy of single detection and combined detection were calculated. Results The positive rate and level of serum AFP, CA125 and CA199 in malignant tumor patients were significantly higher than those in benign lesions and normal controls (P <0.05). The sensitivity, specificity and accuracy of AFP + CEA + CA199 increased to 67.25%, 84.43% and 78.92%, respectively, which were all higher than those of combined detection and single detection (P <0.05). Conclusion Combined detection of serum AFP, CA125 and CA199 can improve the diagnostic efficacy of cervical cancer.