论文部分内容阅读
目的:研究降低血压波动性(BPV)在尼群地平和阿替洛尔合用对高血压大鼠的器官保护中的重要作用.方法:自发性高血压大鼠食物中给予尼群地平(10mg·kg~(-1)·d~(-1)和阿替洛尔(20 mg·kg~(-1)·d~(-1)12周.结果:尼群地平和阿替洛尔合用明显降低自发性高血压大鼠的血压和BPV,明显增高其动脉压力感受性反射敏感性(BRS),并且有效减轻其终末器官损伤.左心室肥厚指数、主动脉肥厚指数和肾小球硬化积分都与血压和 BPV呈正相关,而与 BRS呈负相关.多重回归的结果显示,左心室肥厚和主动脉肥厚减轻主要与收缩期BPV的降低相关,而肾脏损伤的改善主要决定于BRS的增高.结论:尼群地平和阿替洛尔合用长期治疗能有效减轻自发性高血压大鼠的终末器官损伤.这种保护作用除与其降低血压有关外,还与其降低BPV和增高BRS有重要关系.
OBJECTIVE: To study the important role of lowering blood pressure variability (BPV) in the protection of organ in hypertensive rats by combination of nitrendipine and atenolol.Methods: Nitrendipine (10 mg · kg -1 d -1 and atenolol 20 mg · kg -1 -1 d -1 for 12 weeks.Results: The combination of nitrendipine and atenolol was significantly Reduce blood pressure and BPV in spontaneously hypertensive rats, significantly increase their arterial baroreflex sensitivity (BRS), and effectively reduce their terminal organ damage.Left ventricular hypertrophy index, aortic hypertrophy index and glomerular sclerosis score Positive correlation with BP and BPV and negatively correlated with BRS.Results of multiple regression showed that the reduction of left ventricular hypertrophy and aortic hypertrophy were mainly associated with the decrease of BPV in systole and the improvement of renal injury was mainly determined by the increase of BRS. : Long-term treatment with nitrendipine and atenolol can effectively reduce the terminal organ damage in spontaneously hypertensive rats, which is not only related to the reduction of blood pressure, but also to the reduction of BPV and the increase of BRS.