论文部分内容阅读
目的:探讨人体脂肪因子、胰岛素抵抗与非酒精性脂肪性肝病(NAFLD)之间的关系。方法:检测NAFLD患者及对照组人群血浆脂肪因子瘦素、脂联素、抵抗素及胰岛素敏感指数,通过logistic回归分析脂肪因子在非酒精性脂肪肝发病中的变化。结果:NAFLD组的体质指数(BMI)及腰臀比(WHR)显著高于正常对照组(P<0.05)。NAFLD组脂联素与正常对照组相比差异无显著性意义(P>0.05),而NAFLD组的甘油三酯、瘦素及抵抗素显著高于正常对照组(P<0.05),NAFLD组的胰岛素敏感指数显著低于正常对照组(P<0.05)。Logistic回归分析发现WHR、抵抗素是非酒精性脂肪肝发病的独立危险因素。结论:WHR、抵抗素在非酒精性脂肪肝发病中具有重要作用。
Objective: To investigate the relationship between human adipokines, insulin resistance and non-alcoholic fatty liver disease (NAFLD). Methods: The plasma adiponectin, leptin, adiponectin, resistin and insulin sensitivity index were detected in NAFLD patients and controls. The changes of adipokines in nonalcoholic fatty liver disease were analyzed by logistic regression. Results: Body mass index (BMI) and waist-hip ratio (WHR) in NAFLD group were significantly higher than those in normal control group (P <0.05). In NAFLD group, there was no significant difference between adiponectin and normal control group (P> 0.05), but triglyceride, leptin and resistin in NAFLD group were significantly higher than those in normal control group (P <0.05) Insulin sensitivity index was significantly lower than the normal control group (P <0.05). Logistic regression analysis showed that WHR and resistin were independent risk factors for non-alcoholic fatty liver disease. Conclusion: WHR and resistin play an important role in the pathogenesis of nonalcoholic fatty liver disease.