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目的分析糖皮质激素辅助治疗在儿童肺炎支原体感染性大叶性肺炎临床治疗中的价值。方法选取2012年4月-2016年4月在该院接受治疗的肺炎支原体感染性大叶性肺炎患儿142例,根据随机分配原则,将142例患儿分成对照组与观察组,每组71例。对照组采用常规治疗方法,观察组在常规治疗基础上应用糖皮质激素辅助治疗。两组患儿治疗后比较分析临床疗效和不良反应发生情况。结果治疗后,观察组治疗总有效率为97.2%,明显高于对照组的60.6%(P<0.05)。观察组患儿退热时间、咳嗽缓解时间和肺部X片检查恢复正常的时间明显短于对照组(P<0.05)。治疗后,观察组患儿炎性指标白细胞介素-6(IL-6)、白细胞介素-2(IL-2)、血沉(ESR)和C反应蛋白(CRP)的改善程度明显优于对照组(P<0.05)。观察组治疗中不良反应发生情况较少,与对照组比较,差异无统计学意义(P>0.05)。结论糖皮质激素辅助在儿童肺炎支原体感染性大叶性肺炎的临床治疗中效果好,不良反应发生少。
Objective To evaluate the value of glucocorticoid adjuvant therapy in the treatment of children with Mycoplasma pneumoniae Mycoplasma pneumonia. Methods From April 2012 to April 2016, 142 children with Mycoplasma pneumoniae Mycoplasma pneumonia were treated in this hospital. According to the random assignment principle, 142 children were divided into control group and observation group, with 71 example. The control group was treated by conventional method. The observation group was given glucocorticoid adjuvant therapy on the basis of routine treatment. Two groups of children after treatment compared the clinical efficacy and adverse reactions. Results After treatment, the total effective rate in the observation group was 97.2%, significantly higher than that in the control group (60.6%, P <0.05). The observation group patients with fever, cough relief time and lung X-ray examination returned to normal time was significantly shorter than the control group (P <0.05). After treatment, the improvement of IL-6, IL-2, ESR and C-reactive protein in the observation group was significantly better than that of the control group Group (P <0.05). Adverse reactions in the observation group were less, compared with the control group, the difference was not statistically significant (P> 0.05). Conclusion Glucocorticoid-assisted therapy is effective in the clinical treatment of Mycoplasma pneumoniae Mycoplasma pneumoniae with fewer adverse reactions.