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为了解窒息新生儿血小板数 (PLT)、血小板平均容体 (MPV)及血小板分布宽度 (PDW)的变化及其临床意义。方法 采用全自动血细胞分析仪测定 83例窒息新生儿及 80例正常新生儿的PLT、MPV及PDW。结果 新生儿窒息后 ,急性期PLT较正常对照组显著降低 (P <0 0 1) ,MPV和PDW则较对照组明显增高 (P <0 0 5 ) ,窒息组恢复期PLT、MPV和PDW与对照组比较 ,其差异无统计学意义 (P >0 0 5 )。且随着窒息程度加重 ,PLT愈下降 (中度组与轻度组比较P <0 0 0 1) ,而MPV、PDW则愈增高 (中度组与轻度组比较P <0 0 5 ,重度组与轻度组比较P <0 0 1)。结论 血小板参数 (PLT、MPV和PDW)可做为项判断新生儿窒息后病情严重程度并监测病情变化的指标。
To investigate the changes of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) in neonates with asphyxia and its clinical significance. Methods The PLT, MPV and PDW in 83 asphyxiated neonates and 80 normal neonates were determined by automatic hematology analyzer. Results After neonatal asphyxia, PLT in acute phase was significantly lower than that in control group (P <0.01), MPV and PDW were significantly higher than those in control group (P <0.05), PLT, MPV and PDW in recovery phase of asphyxia group There was no significant difference in the control group (P> 0.05). PLT decreased with increasing degree of asphyxia (P <0 0 01 for moderate and mild groups, and more severe for MPV and PDW) (P <0.05 for moderate and mild groups, severe Group and mild group P <0 0 1). Conclusion Platelet parameters (PLT, MPV and PDW) can be used as indicators to judge the severity of neonatal asphyxia and to monitor the changes of the disease.