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目的探讨急性脑梗死应用氯吡格雷和阿司匹林联合治疗的效果。方法 104例急性脑梗死患者,随机分为对照组与观察组,每组52例。对照组采取常规治疗,观察组在对照组基础上采取氯吡格雷和阿司匹林联合治疗。对比两组患者治疗前后的Barthel指数评分(BI指数评分)、简化Fugl-Meyer运动评分(简化FMA评分)及改良Ashworth评分(MAS评分),综合评价患者的疗效。结果治疗前两组BI指数评分、简化FMA评分及MAS评分比较差异无统计学意义(P>0.05),治疗后观察组患者的BI指数评分、简化FMA评分及MAS评分改善程度显著优于对照组,差异具有统计学意义(P<0.05);观察组临床总有效率为90.38%,显著优于对照组的73.08%,差异具有统计学意义(P<0.05)。结论急性脑梗死应用氯吡格雷和阿司匹林联合治疗的效果显著,可显著延缓病情的发展,改善患者的预后,促进病情的恢复,值得临床推广使用。
Objective To investigate the effect of combination therapy with clopidogrel and aspirin in patients with acute cerebral infarction. Methods A total of 104 patients with acute cerebral infarction were randomly divided into control group and observation group, with 52 cases in each group. Control group to take conventional treatment, the observation group on the basis of the control group to take clopidogrel and aspirin combination therapy. The Barthel index score (BI index score), the simplified Fugl-Meyer motor score (simplified FMA score) and the modified Ashworth score (MAS score) were compared between the two groups before and after treatment to evaluate the efficacy of the treatment. Results There was no significant difference in BI index score, simplified FMA score and MAS score between the two groups before treatment (P> 0.05). After treatment, the BI index score, simplified FMA score and MAS score in the observation group were significantly better than those in the control group , The difference was statistically significant (P <0.05). The total clinical effective rate in the observation group was 90.38%, which was significantly better than that in the control group (73.08%). The difference was statistically significant (P <0.05). Conclusion The combination therapy of clopidogrel and aspirin in patients with acute cerebral infarction has significant effect, which can significantly delay the progression of the disease, improve the prognosis of the patients and promote the recovery of the disease. It is worthy of clinical promotion.