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目的 :研究每日顿服钙拮抗剂氨氯地平 (半衰期 3 5～ 5 0h)对于稳定型心绞痛患者心肌缺血昼夜发作方式的影响。方法 :按随机双盲安慰剂对照法 ,将 3 6例稳定型心绞痛患者分为治疗组和对照组 ,两组比例为 2∶1。口服氨氯地平剂量为 5mg/d(第 3周开始至第 5周末 )、10mg/d(第 6周开始至第 10周末 ) ,对照组口服安慰剂。结果 :治疗组心绞痛发作次数的中位数下降 70 % ,而对照组为 44 % ,79%的治疗组病例诉心绞痛发作次数减少 ,而对照组为 5 9% (P =0 .0 0 0 1)。结论 :日服 1次氨氯地平 ,特别是合用 β受体阻滞剂能在 2 4h内有效地缓解心绞痛患者心肌缺血的发作。
Aims: To study the effect of amlodipine, a daily calcium antagonist, on the pattern of diurnal and seizure of myocardial ischemia in patients with stable angina pectoris (half-life 35-500h). Methods: According to a randomized, double-blind, placebo-controlled trial, 36 patients with stable angina were divided into treatment group and control group. The ratio of the two groups was 2: 1. Oral amlodipine dose of 5mg / d (beginning of the third week to the fifth weekend), 10mg / d (beginning of week 6 to the end of the 10th weekend), the control group oral placebo. RESULTS: Median angina pectoris episodes decreased by 70% in the treatment group compared with 44% in the control group, while 79% in the treatment group had fewer episodes of angina pectoris compared with 59% in the control group (P = .0 0 0 1 ). Conclusion: Amlodipine, especially combined with β-blocker, can effectively relieve myocardial ischemia in patients with angina pectoris within 24 hours.