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采用酶联免疫吸附试验 (ELISA)和细胞生物活性法检测了 80例乙型肝炎患者白细胞介素 6 (IL - 6 )和血小板源生长因子 (PDGF)水平 ,结果表明 :急性肝炎、慢性肝炎和肝硬化患者的IL - 6和PDGF的活性明显高于正常对照组 ,且与患者的血清Ⅲ型前胶原肽 (PCⅢ )含量密切相关 ,揭示IL - 6和PDGF活性的变化可能与肝纤维化的发病机制有关
The levels of interleukin - 6 (IL - 6) and platelet derived growth factor (PDGF) in 80 patients with hepatitis B were detected by enzyme linked immunosorbent assay (ELISA) and cell biological activity assay. The results showed that acute hepatitis, chronic hepatitis and The activity of IL - 6 and PDGF in patients with cirrhosis was significantly higher than that of the normal control group, and closely correlated with the level of PC Ⅲ in patients with cirrhosis. The changes of IL - 6 and PDGF activity may be related to the changes of liver fibrosis Pathogenesis related