许多佐剂诱导干扰素(IFN)的能力不同,佐剂诱导的IFN可以影响佐剂本身增强迟发型超敏反应(DH)的作用。本文比较了溴化二甲基双十八烷基铵(DDA)、多聚肌苷酸多聚胞苷酸(polyI:C)、脂质体和多元醇L101、L121诱导BALB/c小鼠产生IFN的能力和对抗原[溶菌酶和灭活的西门利克森林病毒(SFV)]的DH的佐剂作用。实验结果表明,带阴电荷的脂质体和多元醇L121缺乏诱导IFN的能力,也不能增强对SFV的DH。多元醇L101可诱导小鼠产生 Many adjuvants differ in their ability to induce interferon (IFN), and adjuvant-induced IFN can influence the adjuvant itself to potentiate the effects of delayed-type hypersensitivity (DH). In this paper, BALB / c mice were induced by dimethyldioctadecylammonium bromide (DDA), polylysine polycytidylic acid (polyI: C), liposomes and polyols L101 and L121 IFN and the adjuvant effect on DH of antigen [lysozyme and inactivated virion (SFV)]. The experimental results show that the negatively charged liposomes and polyol L121 lack the ability to induce IFN nor enhance the DH against SFV. Polyol L101 induces mouse production