论文部分内容阅读
目的了解平顶山市2009—2013年手足口病病原学特征,为平顶山市手足口病防治提供科学依据。方法采用反转录聚和酶链反应(RT-PCR)或实时荧光RT-PCR的方法,对送检的手足口病标本进行肠道病毒通用型、肠道病毒71型(EV71)、和柯萨奇病毒A16型(CoxA16型)特异核酸检测。结果平顶山市2009—2013年手足口病实验室诊断病例为1 918例,2009—2012年优势病原为EV71,2013年优势病原为CoxA16;不同月份优势病原有所不同;市区和郊县病原构成差异有统计学意义(P<0.001);不同性别间病原构成差异无统计学意义(P=0.072),不同职业间病原构成差异有统计学意义(P=0.010),不同年龄组间差异无统计学意义(P=0.350),重症病例与普通病例病原构成差异有统计学意义(P<0.001),且EV71比例与重症率呈正相关(r=0.806)。结论平顶山市要加强手足口病病原学监测,有效控制手足口病的蔓延。
Objective To understand the etiological characteristics of HFMD in Pingdingshan from 2009 to 2013 and provide a scientific basis for the prevention and treatment of HFMD in Pingdingshan. Methods RT-PCR or real-time RT-PCR methods were used to detect EVH, EV71, Saki virus type A16 (CoxA16 type) specific nucleic acid detection. Results There were 1 918 laboratory diagnosed cases of HFMD in Pingdingshan from 2009 to 2013. The predominant pathogen was EV71 from 2009 to 2012 and CoxA16 from 2013. The prevalence of different pathogens in different months was different. The difference was statistically significant (P <0.001). There was no significant difference in pathogen composition between different sexes (P = 0.072). There was significant difference in pathogens among different occupations (P = 0.010). There was no statistic difference among different age groups (P = 0.350). There was a significant difference in pathogen composition between severe cases and common cases (P <0.001), and there was a positive correlation between EV71 and severe cases (r = 0.806). Conclusion Pingdingshan City should strengthen the hand-foot-mouth disease etiology monitoring, effectively control the spread of hand-foot-mouth disease.