论文部分内容阅读
目的探讨放疗时机对采用诱导化疗的局限期小细胞肺癌患者生存期及生存质量的影响。方法选取2010年12月—2011年12月黄冈市黄梅县人民医院收治的局限期小细胞肺癌患者84例,根据化疗时机分为对照组和观察组,每组42例。观察组患者在化疗2~3个周期时进行同步放疗,对照组患者在化疗4~6个周期时进行同步放疗。比较两组患者生存期、生存质量评分及复发情况。结果观察组患者生存期长于对照组(P<0.05)。观察组患者生理功能、社会功能、生活职能、躯体疼痛、精神健康、情感职能、活力、总体健康评分均高于对照组(P<0.05)。观察组患者复发率低于对照组(P<0.05)。结论尽早接受放疗能延长采用诱导化疗的局限期小细胞肺癌患者生存期,提高患者生活质量。
Objective To investigate the effect of radiotherapy timing on survival and quality of life in patients with locally advanced small cell lung cancer treated with induction chemotherapy. Methods Eighty-four patients with localized SCLC who were admitted to Huangmei People’s Hospital of Huanggang from December 2010 to December 2011 were selected and divided into control group and observation group according to the timing of chemotherapy. Each group included 42 patients. Patients in the observation group were treated with concurrent radiotherapy 2 to 3 cycles of chemotherapy and patients in the control group received concurrent radiotherapy 4 to 6 cycles of chemotherapy. Survival, quality of life scores and recurrence were compared between the two groups. Results The survival time of observation group was longer than that of control group (P <0.05). The physical, social, life functions, physical pain, mental health, emotional function, vitality and overall health of the observation group were higher than those of the control group (P <0.05). The recurrence rate in observation group was lower than that in control group (P <0.05). Conclusions As soon as possible, radiotherapy can prolong the survival of patients with locally advanced small cell lung cancer induced by chemotherapy and improve the quality of life of patients.