论文部分内容阅读
目的探讨亮丙瑞林联合来曲唑治疗绝经前期子宫肌瘤的临床效果。方法选取2010—2014年曲阳仁济医院收治的子宫肌瘤患者86例,随机分为对照组(41例)与观察组(45例)。对照组患者给予亮丙瑞林治疗,观察组患者在对照组基础上加用来曲唑治疗。观察两组患者症状改善情况、临床疗效、性激素水平及不良反应发生情况。结果治疗后两组患者闭经、贫血症状均得到纠正,头晕、乏力、下腹痛等症状均得到缓解;观察组患者临床疗效优于对照组,差异有统计学意义(P<0.05);治疗前两组患者黄体生成素(LH)、促卵泡激素(FSH)、雌二醇(E2)及孕酮(P)水平比较,差异无统计学意义(P>0.05),治疗后观察组患者LH、FSH、E2水平低于对照组(P<0.05),两组患者P水平比较,差异无统计学意义(P>0.05);观察组患者颜面潮红、出汗、易躁、阴道干燥发生率低于对照组(P<0.05)。结论亮丙瑞林联合来曲唑治疗绝经前期子宫肌瘤的临床效果显著,能降低性激素水平,减少不良反应的发生。
Objective To investigate the clinical efficacy of leuprolide combined with letrozole in the treatment of premenopausal uterine fibroids. Methods Totally 86 patients with uterine leiomyoma treated in Quyang Yanji Hospital from 2010 to 2014 were randomly divided into control group (n = 41) and observation group (n = 45). Patients in the control group were treated with leuprolide, and patients in the observation group were treated with letrozole on the basis of the control group. To observe the two groups of patients to improve the symptoms, clinical efficacy, sex hormone levels and adverse reactions. Results After treatment, the symptoms of amenorrhea and anemia in both groups were corrected. The symptoms such as dizziness, fatigue and lower abdominal pain were relieved. The clinical efficacy of the observation group was better than that of the control group (P <0.05) There was no significant difference in the levels of LH, FSH, E2 and progesterone between the two groups (P> 0.05). After treatment, the levels of LH, FSH (P <0.05). There was no significant difference in P level between the two groups (P> 0.05). The incidences of facial flushing, sweating, irritability and vaginal dryness in the observation group were lower than those in the control Group (P <0.05). Conclusion Leuprorelin combined with letrozole treatment of premenopausal uterine fibroids clinically significant effect, can reduce the level of sex hormones and reduce the incidence of adverse reactions.