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目的探索幽门螺杆菌感染与肺癌之间的关系。方法在Pubmed、Embase、万方、维普、中国知网等数据库中进行文献检索,筛选研究幽门螺杆菌感染与肺癌之间关系的文献,提取数据并利用Meta分析进行定量综合分析,计算合并比值比及其95%可信区间(95%CI)。所有统计操作由Stata12.0软件进行。结果本次Meta分析共纳入8篇文献,共2 153例研究对象,包括病例组1 061例,对照组1 092例。病例组与对照组中的幽门螺杆菌感染率存在显著差异,Meta分析显示合并比值比为1.15(95%CI:1.01~1.31),P=0.035。结论幽门螺杆菌感染与肺癌密切相关,可能是肺癌的重要致病因素。
Objective To explore the relationship between Helicobacter pylori infection and lung cancer. Methods Literature search was carried out in databases such as Pubmed, Embase, Wanfang, VIP, CNKI and so on. The literature on the relationship between Helicobacter pylori infection and lung cancer was screened, and the data were extracted and analyzed quantitatively using Meta analysis. And 95% confidence interval (95% CI). All statistical operations by Stata12.0 software. Results A total of 2 153 articles were included in this Meta-analysis, including 1,061 cases in the case group and 1,092 cases in the control group. There was a significant difference in Helicobacter pylori infection rates between the case and control groups. Meta-analysis showed a pooled odds ratio of 1.15 (95% CI: 1.01 to 1.31), P = 0.035. Conclusion Helicobacter pylori infection is closely related to lung cancer and may be an important risk factor for lung cancer.