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目的探讨匹多莫德治疗小儿反复下呼吸道感染的临床疗效及其对免疫功能的影响。方法将我院2011年7月—2012年5月收治的100例反复下呼吸道感染的患儿按照治疗方法的不同分为治疗组和对照组,每组50例,对照组采用抗感染及对症治疗,治疗组在对照组的基础上采用匹多莫德治疗,比较二组的疗效及免疫功能的变化。结果治疗组中显效31例,有效15例,总有效率为92.0%,显著高于对照组的72.0%(P<0.05)。治疗后治疗组的CD4+、CD4+/CD8+显著高于对照组,IgE显著低于对照组(P<0.05)。结论匹多莫德能显著提高反复下呼吸道感染患儿的免疫力,提高治疗效果,减少复发。
Objective To investigate the clinical efficacy of pidotimod in children with recurrent lower respiratory tract infection and its effect on immune function. Methods 100 cases of recurrent lower respiratory tract infection in our hospital from July 2011 to May 2012 were divided into treatment group and control group according to the different treatment methods. Each group was treated with anti-infective and symptomatic treatment , The treatment group was treated with Pidotimod on the basis of the control group, and the curative effect and immune function of the two groups were compared. Results In the treatment group, 31 cases were markedly effective and 15 cases were effective. The total effective rate was 92.0%, which was significantly higher than that of the control group (72.0%, P <0.05). After treatment, the levels of CD4 +, CD4 + / CD8 + in the treatment group were significantly higher than those in the control group, and IgE was significantly lower than that in the control group (P <0.05). Conclusion Pidotimod can significantly improve the immunity of children with recurrent lower respiratory tract infection, improve the therapeutic effect and reduce the relapse.