• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 期刊论文
  5. Pharmacophore-guided design, synthesis and evaluation of quinazoline-arylpiperazines as new α1-adren

Pharmacophore-guided design, synthesis and evaluation of quinazoline-arylpiperazines as new α1-adren

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：tiger10208
【摘 要】
：
A series of arylpiperazinesquinazoline-2,4-diamine compounds were designed and synthesized based on pharmacophore for uro-selective α1-adrenoceptor antagonists
【作 者】
：
Hao Fang Min Yong Li Lin Xia 
【机 构】
：
School of Pharmacy,Department of Medicinal Chemistry
【出 处】
：
中国化学快报（英文版）
【发表日期】
：
2004年期
【关键词】
：
α1-Adrenoceptor Antagonists Pharmacophore-guided design 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
A series of arylpiperazinesquinazoline-2,4-diamine compounds were designed and synthesized based on pharmacophore for uro-selective α1-adrenoceptor antagonists and 3D chemical database searching. The in vitro functional analysis showed that compounds 9 and 14 showed better and similar α1-AR antagonistic activity compared with prazosin.
其他文献
Evidence of the Link between Broad Emission Line Regions and Accretion Disks in Active Galactic Nucl
There is observational evidence that broad-line regions (BLRs) exist in most active galactic nuclei (AGNs), but their origin is still unclear. One scenario is t
期刊
accretionaccretion disks-galaxies: active-galaxies: theory- radiation mechanism
A LOCKING-FREE ANISOTROPIC NONCONFORMING FINITE ELEMENT FOR PLANAR LINEAR ELASTICITY PROBLEM
The main aim of this article is to study the approximation of a locking-free anisotropic nonconforming finite element for the pure displacement boundary value p
期刊
Locking-freeplanar linear elasticityanisotropic nonconforming finite elemento
Data Processing Model of Coalmine Gas Early-Warning System
The data processing mode is vital to the performance of an entire coalmine gas early-warning system, especially in real-time performance. Our objective was to p
期刊
gas early-warningdata processingqueuing theorypriority modelhigh efficiency
Determination of Pesticide Ethion by Linear Sweep Stripping Voltammetry
The presence of the pesticide ethion was determined using an electroanalytical method, i. e. , linear sweep stripping voltammetry at a hanging mercury drop elec
期刊
EthionLinear sweep stripping voltammetryVegetable sample
Synthesis and Crystal Structure of 4-{[(1E)1-(2-Hydroxy-3-methoxyphenyl)methylidene] amino}-1,5-dime
The title Schiff base compound,C19H19N3O3,a derivative of antipyrine,has been synthesized and characterized by elemental analysis,IR,and single-crystal X-ray di
期刊
Schiff baseantipyrine derivativecrystal structureantibacterial activities
On gl((⌒)2｜2)(2)k Current Superalgebra and Twisted Conformal Field Theory
Motivated by the recently discovered hidden symmetry of the type ∏B Green-Schwarz superstring on certain background, the non-semisimple Kac-Moody twisted super
期刊
superalgebradifferential operator realizationfree field realizationconformal
A Statistical Analysis of Point-like Sources in the Chandra Galactic Center Survey
The Chandra Galactic Center Survey detected ～ 800 X-ray point-like sources in the 2°× 0.8° sky region around the Galactic Center. We study the spatial and lum
期刊
methods: data analysis - Galaxy: center - X-ray: stars
CONE-DIRECTED CONTINGENT DERIVATIVES AND GENERALIZED PREINVEX SET-VALUED OPTIMIZATION
By using cone-directed contingent derivatives, the unified necessary and sufficient optimality conditions are given for weakly and strongly minimal elements res
期刊
Preinvex set valued optimizationcone-directed contingent derivativeoptimality
Visual Simulation of Multiple Unmixable Fluids
We present a novel grid-based method for simulating multiple unmixable fluids moving and interacting.Unlike previous methods that can only represent the interfa
期刊
computational fluid dynamicsnatural phenomenaphysically based animation