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自50年代至80年代,陆续报道证明慢性饲以氨基酸限定甲基缺乏食物而导致的肝脏形态学和酶的改变与肝癌形成过程中所见的改变相似。为此,本研究旨在进一步探讨膳食中去除甲基对于肝癌形成的作用。实验用动物为刚断乳的雄性Fischer大鼠,共344只。首先分成两大组,一组以二乙基亚硝胺(DENA)作为起动剂,一组不经DENA处理。然后喂以完全的,氨基酸限定的饲料一周,并按20、70或200 mg/kg体重腹
From the 1950s to the 1980s, changes in liver morphology and enzymes caused by chronic diet-induced amino acid-limited methyl-deficiency foods were reported in succession similar to those seen during hepatocarcinogenesis. To this end, this study aims to further explore the role of dietary methyl removal for the formation of liver cancer. A total of 344 male Fischer rats were used as experimental animals. First divided into two groups, one group with diethylnitrosamine (DENA) as a starter, one without DENA treatment. Then fed a full, amino acid-limited feed for one week and fed at 20, 70 or 200 mg / kg body weight