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目的探讨向心性肥胖和糖尿病对绝经后女性垂体功能的影响及外周类固醇激素的改变。方法比较正常绝经前妇女(NC1组)、正常绝经后妇女(NC2组)、绝经后糖尿病非肥胖组(DM组)和糖尿病向心性肥胖组(DM+Ob组)的一般临床特征、垂体激素和外周类固醇激素水平的改变。结果 DM+Ob组的血糖、胰岛素、HOMA-IR和TG均较DM组和NC1组、NC2组高(P<0.05)。DM+Ob组和DM组的外周血中,FSH和LH均显著低于NC2组,而且血FSH的浓度在DM+Ob组中也显著低于DM组(P<0.05)。其他垂体前叶激素(ACTH、GH、TSH和PRL)DM+Ob组0.05)。结论糖尿病合并向心性肥胖的绝经后妇女出现垂体促性腺激素分泌细胞功能受损。
Objective To investigate the effects of central obesity and diabetes on pituitary function in postmenopausal women and the changes of peripheral steroid hormones. Methods The clinical features of normal menopause women (NC1 group), normal postmenopausal women (NC2 group), postmenopausal diabetic non-obese group (DM group) and diabetes mellitus obesity group (DM + Ob group) Changes in peripheral steroid hormone levels. Results The blood glucose, insulin, HOMA-IR and TG in DM + Ob group were higher than those in DM group and NC1 group and NC2 group (P <0.05). The levels of FSH and LH in peripheral blood of DM + Ob group and DM group were significantly lower than that of NC2 group, and the concentration of FSH in DM + Ob group was also significantly lower than DM group (P <0.05). Other pituitary hormone (ACTH, GH, TSH and PRL) DM + Ob group 0.05). Conclusions Pituitary gonadotropin-secreting cells are impaired in postmenopausal women with diabetes mellitus with central obesity.