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目的 研究持续气道正压（ CPAP）治疗对阻塞性睡眠呼吸暂停综合征（ OSAS）患者夜间多尿的影响及其与夜间心钠素水平的关系。方法 记录患者 CPAP治疗前后的夜尿次数、夜尿量、夜尿渗透压、夜尿钠排泄量和夜间心钠素 (ANP)。结果 CPAP治疗后 OSAS患者夜尿次数、夜尿量、夜尿钠排泄量明显减少，夜尿渗透压明显增高，夜间 ANP明显降低； ANP降低值与夜尿量、夜尿渗透压和夜尿钠排泄量的改变值有显著相关性。结论 CPAP治疗可明显减少 OSAS患者夜尿次数和夜尿量，减少夜尿钠排泄量，增加夜尿渗透压，这些改变可能与 ANP的降低有关。
Objective To investigate the effect of continuous positive airway pressure (CPAP) on nocturnal polyuria in obstructive sleep apnea syndrome (OSAS) patients and its relationship with nocturnal atrial natriuretic peptide (NAA) level. Methods The number of nocturnal urination, nocturia, nocturnal urine osmolality, nocturia and nocturnal atrial natriuretic peptide (ANP) were recorded before and after CPAP treatment. Results The number of nocturnal urination, nocturnal urinary sodium excretion and nocturnal urinary excretion of OSAS patients after CPAP treatment were significantly decreased, and the osmotic pressure of nocturia was significantly increased at night, and the ANP was significantly decreased at night. The decreased ANP and nocturnal urine sodium, There was a significant correlation between changes in excretion. Conclusion CPAP treatment can significantly reduce the number of nocturnal urination and nocturnal urine output in patients with OSAS, reduce nocturia and excretion of nocturnal urine, and these changes may be related to the reduction of ANP.