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1966年由Magerlein等人以氯离子取代林可霉素分子中第七位的羟基首次合成克林霉素。与林可霉素相比,克林霉素的抗菌活性增强4~8倍。其特点是抗菌活性强、抗菌谱广,对许多革兰阳性需氧菌、厌氧菌具有很高的抗菌活性。对衣原体、支原体、恶性疟原虫和弓形虫也有活性。可用于治疗多种感染。克林霉素的作用机制克林霉素作用于细菌核糖体的50S亚单位,通过抑制肽链的延长而抑制细
In 1966, Magerlein et al. Substituted clindamycin for the first time by substituting chloride for the seventh hydroxyl in lincomycin. Compared with lincomycin, the antibacterial activity of clindamycin increased by 4 to 8 times. It is characterized by strong antibacterial activity, broad antibacterial spectrum, for many gram-positive aerobic bacteria, anaerobic bacteria have a high antibacterial activity. Chlamydia, Mycoplasma, Plasmodium falciparum and Toxoplasma gondii also active. Can be used to treat multiple infections. Mechanism of Clindamycin Clindamycin acts on the 50S subunit of bacterial ribosomes and inhibits the fine