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目的了解婴幼儿围手术期是否存在胰岛素抵抗及术后胰岛素抵抗的程度,初步探讨相关干预措施对围手术期胰岛素抵抗的影响。方法随机选取接受择期手术的40例婴幼儿,分成实验组和对照组。对照组手术前夜依常规禁食,实验组手术前夜静脉给予葡萄糖至麻醉诱导前约2~3h,葡萄糖输入速度为5mg.kg-1.min-1。比较二组手术前后及组间的胰岛素敏感性。结果实验组与对照组手术前后胰岛素敏感性的差异在统计学上具有显著性意义(P<0.05);术前二组胰岛素敏感性没有显著差异(P>0.05),术后实验组和对照组胰岛素敏感性差异具有显著性(P<0.05)意义。对照组亚组之间手术前后胰岛素敏感性差异没有显著性意义(P>0.05)。结论婴幼儿择期手术后存在胰岛素抵抗,术前给予适当的糖负荷可以降低婴幼儿择期手术后的胰岛素抵抗。
Objective To understand whether perioperative infants and young children with insulin resistance and postoperative insulin resistance, and to explore the impact of interventions on perioperative insulin resistance. Methods Forty infants who underwent elective surgery were randomly divided into experimental group and control group. The control group was routinely fasted on the eve of surgery. The experimental group received glucose intravenously before surgery for about 2 to 3 hours before induction of anesthesia. The glucose infusion rate was 5 mg.kg-1.min-1. The insulin sensitivity of the two groups before and after surgery and between groups was compared. Results The difference of insulin sensitivity between experimental group and control group before and after surgery was statistically significant (P <0.05). There was no significant difference in insulin sensitivity between experimental group and control group before and after operation (P> 0.05) Insulin sensitivity difference was significant (P <0.05) significance. There was no significant difference in the insulin sensitivity between the control group and the subgroup before and after surgery (P> 0.05). Conclusion Infants and young children have insulin resistance after elective surgery. Preoperative glucose load can reduce the insulin resistance of infants after elective surgery.