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目的 :研究丁酸钠灌肠治疗对结肠炎临床表现、粘膜损伤的改善作用及其与凋亡有关的可能机制。方法 :用醋酸诱导大鼠结肠炎 ,3d后随机分为三组 ,每天分别给予丁酸钠、5 氨基水杨酸和 0 .9%氯化钠溶液灌肠 1次。于第11天处死 ,进行结肠损伤指数评分及组织还原型谷胱甘肽 (GSH)和黄嘌呤氧化酶 (XOD)的测定。结果 :0 .9%氯化钠溶液灌肠组 ,腹泻及结肠损伤持续存在 ,结肠损伤指数明显高于丁酸钠灌肠治疗组和 5 氨基水杨酸灌肠治疗组。而丁酸钠灌肠治疗组 ,腹泻及结肠均恢复正常 ,且均与组织的GSH、XOD水平相关。结论 :丁酸盐灌肠治疗可刺激结肠损伤修复 ,表现为临床症状好转 ,炎症抑制及相应指标改善。提示丁酸盐治疗溃疡性结肠炎的广阔前景。
Objective: To study the effect of sodium butyrate enema on the clinical manifestations of colitis, mucosal injury and its possible mechanism of apoptosis. Methods: The colitis was induced by acetic acid in rats. After three days, the mice were randomly divided into three groups. Sodium butyrate, 5-aminosalicylic acid and 0.9% sodium chloride solution were administered enema once daily. The rats were sacrificed on the 11th day for the index of colonic damage index and the determination of glutathione (GSH) and xanthine oxidase (XOD). Results: 0. 9% sodium chloride solution enema group, diarrhea and colon damage persisted, colon injury index was significantly higher than the sodium butyrate enema treatment group and 5 amino acid salicylic acid enema treatment group. The sodium butyrate enema treatment group, diarrhea and colon were returned to normal, and are related to the level of tissue GSH, XOD. CONCLUSION: Butanoate enema treatment can stimulate colon injury repair, showing improvement of clinical symptoms, suppression of inflammation and improvement of corresponding indexes. Tip butyrate for the treatment of ulcerative colitis broad prospects.