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热习服时,机体代谢速率降低,这是已为人们熟知的事实。与之相一致的变化,线粒体呼吸速率(state 3)降低,也为一些学者的工作所证实。对此,Cassuto Y曾提出“化学热抑制”的假说,但进一步的机制并不清楚。近些年来,腺苷酸(ATP、ADP、AMP)对机体代谢的调节作用愈来愈受到人们的重视。Kunz W.等人的实验表明离体线粒体的呼吸速率明显受线粒体外ATP/ADP比值的影响。该比值增加,线粒体呼吸速率降低,反之则升高。若使ATP/ADP比值从100变化到5,可使线粒体从静息状态(state 4)转变到完全活动状态(state 3)。亦有实验证明线粒体内ATP/ADP比值与其呼吸速率之间存在类似的关系。ATP/ADP
It is a well-known fact that during the heat acclimatization, the body’s metabolic rate is reduced. In line with this change, mitochondrial respiratory rate (state 3) decreased, but also for some scholars confirmed the work. In response, Cassuto Y has put forward the hypothesis of “chemical thermal repression”, but the further mechanism is not clear. In recent years, adenylate (ATP, ADP, AMP) regulation of body metabolism more and more attention. Experiments by Kunz W. et al. Showed that the respiration rate of isolated mitochondria was significantly affected by the mitochondrial ATP / ADP ratio. The ratio increased mitochondrial respiratory rate decreased, otherwise increased. Changing the ATP / ADP ratio from 100 to 5 allowed the mitochondria to transition from the resting state 4 to the fully active state 3. Experiments have also shown that there is a similar relationship between the mitochondrial ATP / ADP ratio and its respiration rate. ATP / ADP