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目的提高消咳平喘口服液中定性鉴别方法以及盐酸麻黄碱的含量测定方法,为制定消咳平喘口服液质量标准提供依据。方法修订处方中的定性测定方法;采用高效液相色谱法定量测定处方中盐酸麻黄碱的含量。结果薄层鉴别能专属定性分析处方中相关药材,苦杏仁薄层鉴别结果不能列入质量标准;盐酸麻黄碱在浓度为2.992~74.8μg/ml范围内呈良好的线性关系,平均回收率为100.9%(RSD=1.70%)。结论该定性定量方法简便、准确、重复性好,可作为消咳平喘口服液的质量控制方法。
Objective To improve the method of qualitative identification of Xiaoke Pingchuan Oral Liquid and determination of content of ephedrine hydrochloride, and provide the basis for establishing the quality standard of Xiaokepingchuan oral liquid. Methods The method of qualitative determination of prescription was revised. The content of ephedrine hydrochloride in prescription was determined by high performance liquid chromatography. Results Thin layer identification can be dedicated qualitative analysis of prescription herbs, thin layer of bitter almond identification results can not be included in the quality standard; ephedrine hydrochloride in the concentration range of 2.992 ~ 74.8μg / ml showed a good linear relationship with an average recovery of 100.9 % (RSD = 1.70%). Conclusion The qualitative and quantitative method is simple, accurate and reproducible. It can be used as a quality control method for Xiaokepingchuan oral liquid.